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Cardiovascular & Hematopoietic System > Antimigraine Preparations
Divalproex Na 125mg
(Also known as Depakote Sprinkle)
Package Price Order
30 pills $ 59.37
60 pills $ 115.83
90 pills $ 169.41
120 pills $ 220.08
The usual adult dose for treatment of attacks is 1 ml for immediate relief of symptoms. For intermittent and long term treatment, the usual dose is 1-2 ml four times a day.

Dosage and Administration:
The usual dosage for migraine prophylaxis is 500 mg once daily for 1 week, then 1000 mg once daily. For complex partial seizure, the usual adult dose is 10-15 mg/kg/day and increased by 5-10 mg/kg/day. For simple or complex absence seizure, the usual adult dose is 15 mg/kg/day and increased at one week interval by 5-10 mg/kg/day with a maximum dose of 60 mg/kg/day. Each tablet should be taken with food.

This medication is contraindicated to patients with known hypersensitivity to Divalproex Sodium and its ingredients. It is also contraindicated to patients with hepatic dysfunction or urea cycle disorders.

Monitor liver and clotting functions when in Depakote therapy. Use with caution in patients with metabolic disorders, seizure disorders, pancreatitis, hyperammonemia, and thrombocytopenia. Withdrawal of this drug should be done gradually. Use with caution when driving or operating heavy machinery, this drug may cause dizziness and lightheadedness. This drug in not recommended for long term use. Use this drug with caution during pregnancy and lactation. Safety and efficacy of this drug during pregnancy and lactation is not established.

Adverse Reactions:
This medication is generally well tolerated. However, some adverse effects of this drug are reported such as dizziness, dysmenorrhea, pruritus, rash, back pain, hypertension, nervousness, diarrhea, headache, fever, sinusitis, constipation, nausea, dyspepsia, vomiting, abdominal pain, weight loss or gain, palpitation, tachycardia, insomnia, dry mouth, flatulence, UTI, conjunctivitis, and urinary frequency.
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